Fibroblast growth factor receptors (FGFR) are transmembrane kinase proteins with growing importance in cancer biology given the frequency of molecular alterations and vast interface with multiple other signaling pathways.
The FGFR3 gene is at the human chromosomal locus 4p16.3 also encodes two isoforms: FGF R3 (IIIb) FGF R3 (IIIc).
Upregulated expression of FGFR3 protein is also found in a significant number of tumors.
Additionally, FGFR3 has been found to trigger resistance to tamoxifen via the activation of the PLCγ signaling cascade.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 65.0 kDa.
The protein migrates as 80-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human FGF R3 (IIIb), Fc Tag (FGB-H5259) is expressed from human 293 cells (HEK293). It contains AA Glu 23 - Gly 377 (Accession # P22607-2).
