Killer cell immunoglobulin-like receptor 2DL1(KIR2DL1), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells.
Regulation of NK cell activity is mediated through killer-cell immunoglobulin-like receptors (KIR) ability to recognize human leukocyte antigen (HLA) class I molecules as ligands.
Interaction of KIR and HLA is implicated in viral infections, autoimmunity, and reproduction and there is growing evidence of the coevolution of these two independently segregating gene families.
Association of KIR2DL1 with β-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated downstream inhibitory signaling.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 50.7 kDa.
The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human KIR2DL1, Fc Tag (KI1-H5255) is expressed from human 293 cells (HEK293). It contains AA His 22 - Arg 242 (Accession # P43626-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：His 22 - Arg 242
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P43626-1
Protein ID：NP_055033.2
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
