Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor.
Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands.
Also, Integrin alpha-V/beta-3 acts as a receptor for herpes virus 8/HHV-8, coxsackievirus A9, Hantaan virus, cytomegalovirus/HHV-5, human metapneumovirus, human parechovirus 1 and west nile virus.
Furthermore, in case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
特徴
Biotinylated Human ITGAV&ITGB3 Heterodimer Protein, His, Avitag&Tag Free, produced by co-expression of ITGAV and ITGB3, has a calculated MW of 114.6 kDa (ITGAV) and 81.8 kDa (ITGB3).
Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag) and subunit ITGB3 contains no tag but a basic tail at the C-terminus.
The predicted N-terminus is Phe 31 (ITGAV) & Gly 27 (ITGB3).
The non-reducing (NR) protein migrates as 135 kDa (ITGAV) & 80 kDa (ITGB3) respectively due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human ITGAV&ITGB3 Heterodimer Protein, His,Avitag&Tag Free (IT3-H82W9) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) & Gly 27 - Asp 718 (ITGB3) (Accession # P06756-1(V783I) & P05106-1).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His & C-Avi | Native
Exp Region：Phe 31 - Val 992 (ITGAV) & Gly 27 - Asp 718 (ITGB3)
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：P06756-1(V783I) | P05106-1
Protein ID：NP_002201.1 (ITGAV) & AAI27667.1 (ITGB3)
