Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction.
MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites.
Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.
Probably plays a role in maintaining homeostasis on mucosal surfaces.
特徴
This protein carries a mouse IgG2a Fc tag at the C-terminus.
The protein has a calculated MW of 33.4 kDa.
The protein migrates as 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human Mucin-1 (1098-1158), Mouse IgG2a Fc Tag (MU1-H5259) is expressed from human 293 cells (HEK293). It contains AA Ser 1098 - Gly 1158 (Accession # P15941-1).
Species Reactivity：Human
Host：HEK293
Tag：C-mFc(mIgG2a)
Exp Region：Ser 1098 - Gly 1158
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P15941-1
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
