The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface.
Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR).
Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex.
The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 77.6 kDa.
The protein migrates as 80-95 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Sortilin Protein, His Tag (SON-H52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 78 - Asn 755 (Accession # Q99523-1).
