Activin receptor type-2A (ACVR2A) is also known as Activin receptor type IIA, ACTR-IIA, ACTRIIA and ACVR2,which is single-pass type I membrane protein.
ACVR2A belongs to the protein kinase superfamily,TKL Ser/Thr protein kinase family and TGFB receptor subfamily.On ligand binding,ACVR2A can forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases.
Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.ACVR2A is Receptor for activin A, activin B and inhibin A as well.
Several type I I activin receptors have been identified and bind to different activins with different affinities.
特徴
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 39.9 kDa.
The protein migrates as 50-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human ACVR2A, Fc Tag (ACA-H5269) is expressed from human 293 cells (HEK293). It contains AA Ala 20 - Pro 135 (Accession # P27037-1).
Species Reactivity：Human
Host：HEK293
Tag：N-Fc
Exp Region：Ala 20 - Pro 135
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P27037-1
Protein ID：NP_001607.1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
