Fibroblast Growth Factor 10 (FGF 10) is an evolutionary conserved secreted growth factor mediating mostly mesenchymal to epithelial signaling.
FGF 10 belongs to the FGF 7 subfamily and shares similar biochemical and amino acid sequences with its constituent members (FGF3, FGF 7 and FGF 22).
As a paracrine FGF, FGF 10 elicits its biological responses by activating the fibroblast growth factor receptor 2b (FGF R 2b), is crucial for governing proximal distal outgrowth as well as patterning and acts upstream of the known apical ectodermal ridge (AER) marker FGF 8.
FGF10 is also implicated in pancreatic cancer, and that overexpression of FGFR2b is associated with metastatic invasion.
特徴
This protein carries a polyhistidine tag at the N-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 22.9 kDa.
The protein migrates as 27 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：200ug
Source：Biotinylated Human FGF-10, His,Avitag (FG0-H81Q7) is expressed from E. coli cells. It contains AA Gln 38 - Ser 208 (Accession # O15520-1).
