IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG.
IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein.
High-affinity receptor for interleukin-15.
Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells.
Expression of different isoforms may alter or interfere with signal transduction.
An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor.
Signal transduction involves SYK.
Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 44.8 kDa.
The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse IL-15 R alpha, Fc Tag (ILA-M5253) is expressed from human 293 cells (HEK293). It contains AA Gly 33 - Lys 205 (Accession # Q60819-1).
Species Reactivity：Mouse
Host：HEK293
Tag：C-Fc
Exp Region：Gly 33 - Lys 205
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q60819-1
Protein ID：NP_032384.1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
