USAG1 (uterine sensitization associated gene 1), also known asSOSTDC1 (sclerostin domain–containing 1), Ectodin, is a secreted protein with a glycosylated N-terminus that contains a C-terminal cysteine knot domain.
This C-terminal cysteine knot domain is present in numerous growth factors, including TGFβ, NGF, PDGF, vWF, NDP, and mucin-2, and involved in dimerization, receptor binding, and signal transduction.
SOSTDC1 negatively regulates BMP signaling during cellular proliferation, differentiation, and apoptosis in several biological processes (such as dentary morphogenesis, embryo implantation in the endo-metrium, and healing of bone fractures) [8].
In addition, SOSTDC1 might also involve cancer development processes through the regulation of the Wnt pathway.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 47.2 kDa.
The protein migrates as 45-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human USAG-1, Fc Tag (US1-H5254) is expressed from human 293 cells (HEK293). It contains AA Phe 24 - Ser 206 (Accession # Q6X4U4-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Phe 24 - Ser 206
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q6X4U4-1
Protein ID：NP_056279.1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
