Fibroblast growth factor 23 (FGF23) is is an endocrine member of the family of FGFs and mainly produced in the bone and, upon secretion, forms a complex with a FGF receptor and coreceptor αKlotho.
FGF23 can exert several endocrine functions, such as acting as a hormone on the kidney, stimulating phosphate excretion and suppressing formation of 1,25(OH)2D3, active vitamin D.
Moreover, it has paracrine activities on several cell types, including neutrophils and hepatocytes.
FGF23 and phosphate have been revealed to be factors relevant in cancer.
FGF23 is particularly significant for those forms of cancer primarily affecting bone (e.g., multiple myeloma) or characterized by bone metastasis.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 27.3 kDa.
The protein migrates as 30-32 kDa and 33-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human FGF-23 (R179Q), His Tag (FG3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Tyr 25 - Ile 251 (Accession # Q9GZV9-1 (R179Q)).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His
Exp Region：Tyr 25 - Ile 251
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q9GZV9-1 (R179Q)
Protein ID：NP_065689.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：20 mM MOPS, 150 mM NaCl, 5 mM EDTA, 2 mM DTT, pH7.4
