Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures.
It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity.
Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro).
ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.
特徴
Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag, produced by co-expression of ITGA7X1B and ITGB1, has a calculated MW of 115.1 kDa (ITGA7X1B) and 85.0 kDa (ITGB1).
Subunit ITGA7X1B contains no tag but an acidic tail at the C-terminus and subunit ITGB1 contains a polyhistidine tag and a basic tail at the C-terminus.
The non-reducing (NR) protein migrates as 95-115 kDa due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus ITGA7X1B&ITGB1 Heterodimer Protein, Tag Free&His Tag (IT1-C52W3) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Pro 1081 (ITGA7X1B) & Gln 21 - Asp 728 (ITGB1) (Accession # XP_005571182.1 (ITGA7X1B) & XP_015311227.1 (ITGB1)).
Species Reactivity：Cynomolgus
Host：HEK293
Tag：Native | C-10×His
Exp Region：Phe 34 - Pro 1081 (ITGA7X1B) & Gln 21 - Asp 728 (ITGB1)
