Mast/stem cell growth factor receptor Kit (c-Kit), a member of the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily, is also known as piebald trait protein (PBT), p145 c-kit, tyrosine-protein kinase Kit and CD117,which contains five Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain.
CD117 acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.
In response to KITLG/SCF binding, CD117 can activate several signaling pathways.
Furthermore, Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 81.5 kDa.
The protein migrates as 100-115 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse CD117, Fc Tag (CD7-M5259) is expressed from human 293 cells (HEK293). It contains AA Ser 25 - Thr 519 (Accession # P05532-2).
Species Reactivity：Mouse
Host：HEK293
Tag：C-Fc
Exp Region：Ser 25 - Thr 519
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P05532-2
Protein ID：NP_066922.2
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
