83-3858-85　Biotinylated Mouse IL-27 Protein, His,Avitag 200ug　IL7-M82E4-200ug

特徴

• 背景
• Interleukin-27 (IL-27) is a heterodimeric cytokine belonging to the IL-12 family that is composed of two subunits, Epstein-Barr virus (EBV)-induced gene 3 (EBI3) (also known as IL-27B) and IL27-p28 (known as IL-30).
• IL-27 is produced by antigen-presenting cells.
• IL-27 plays an important function in regulating the activity of B and T lymphocytes.
• The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL27R and gp130.
• IL-27 is a cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells.
• Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17).
• It drives rapid clonal expansion of naive but not memory CD4 T-cells.
• IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production.
• IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T cells.
• Another important role of IL-27 is its antitumor activity and antiangiogenic activity.
• 特徴
• This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).
• The protein has a calculated MW of 51.6 kDa.
• The protein migrates as 55 kDa & 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.