DNAX accessory molecule 1 (DNAM-1), a single-pass type I membrane protein, is also known as CD226 antigen and platelet and T cell activation antigen 1 (PTA1), which contains 2 Ig-like C2-type (immunoglobulin-like) domains.
DNAM-1 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells.
DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation.
Furthermore, DNAM-1 can interact with PVR and PVRL2.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 28.1 kDa.
The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Mouse DNAM-1, His Tag (DN1-M52H5) is expressed from human 293 cells (HEK293). It contains AA Glu 19 - His 250 (Accession # Q5DW69-1).
