Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1.
May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.
Contributes to natural killer cell cytotoxicity.
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils.
Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400).
Alpha D beta 2, selectively binds ICAM-3 and does not appear to bind ICAM-1.
In addition, a soluble form of alpha D beta 2 binds VCAM-1 with greater efficiency relative to ICAM-3.
The I domain of alpha D contains a binding site for VCAM-1 since recombinant alpha D I domain binds specifically to VCAM-1.
特徴
Human Integrin alpha D beta 2 (ITGAD&ITGB2) Heterodimer Protein, produced by co-expression of ITGAD and ITGB2, has a calculated MW of 124.9 kDa (ITGAD) and 80.2 kDa (ITGB2).
Subunit ITGAD is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.
The protein migrates as 150 kDa (ITGAD) and 90-100 kDa (ITGB2) under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human ITGAD&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H53W6) is expressed from CHO cells. It contains AA Phe 18 - Asn 1099 (ITGAD) & Gln 23 - Asn 700 (ITGB2) (Accession # Q13349-1 (ITGAD) & P05107-1 (ITGB2)).
