Protein-arginine deiminase type-2 (PADI2) are calcium-dependent histone-modifying enzymes whose activity is dysregulated in inflammatory diseases and cancer.
This enzyme which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions.
The type II enzyme is the most widely expressed family member.
Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 78.3 kDa.
The protein migrates as 66-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Mouse PADI2, His Tag (PA2-M5544) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Pro 673 (Accession # Q08642-1).
