Connective Tissue Growth Factor (CTGF), also known as CCN2, is a member of the CCN (CCN1-6) family of modular matricellular proteins.
Like other CCN proteins, mature human CTGF consists of IGF-binding protein domain, a vWF-C domain, a TSP-1 domain, and a cysteine knot heparin-binding domain.
CTGF promotes proliferation and differentiation of chondrocytes.
Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells.
Enhances fibroblast growth factor-induced DNA synthesis.
Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases.
特徴
This protein carries a human IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 61.9 kDa.
The protein migrates as 48-53 kDa and 65-75 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human CTGF, Fc Tag (GTF-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln27-Ala349 (Accession # Q5M8T4-1 ).
Species Reactivity：Human
Host：HEK293
Tag：N-Fc
Exp Region：Gln27-Ala349
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q5M8T4-1
Protein ID：NP_001892.1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
