83-3857-27　［取扱停止］Human Siglec-10 Protein, Fc （L117A, L118A） Tag 1mg　SI0-H5254-1mg

特徴

• 背景
• The siglecs (sialic acid-binding Ig-like lectins) are a distinct subset of the Ig superfamily with adhesion-molecule-like structure.
• We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs.
• Siglec-10 was identified through database mining of an asthmatic eosinophil EST library.
• The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.
• 特徴
• This protein carries a Fc (L117A, L118A) tag at the C-terminus.
• The protein has a calculated MW of 84.6 kDa.
• The protein migrates as 100-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Mutations (L117A, L118A/EU number: L234A/L235A) in human immunoglobulin G1 (hIgG1) Fc diminish binding to FcγRI leading to a significant reduction in ADCC and CDC in comparison to wild type human IgG1.