The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) takes a key role in the endothelial adhesion and migration of lymphocytes to sites of inflammation in inflammatory disease.
In vitro and in vivo data indicate that blockade of the adhesion molecule mucosal address in cell adhesion molecule (MAdCAM) pathway decreases leukocyte homing to the gut by inhibiting the interaction between MAdCAM and its ligand the α4β7 integrin expressed on lymphocytes.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 59.6 kDa.
The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human MAdCAM-1, Fc Tag (MAM-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Gln 333 (Accession # Q4PKD0-1).
