Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors.
GDF-2 Potent circulating inhibitor of angiogenesis.
Signals through the type I activin receptor ACVRL1 but not other Alks.
Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG.
ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs).
BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells.
Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 47.0 kDa.
The protein migrates as 13 kDa and 40-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Latent GDF-2, His Tag (GD2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Lys 23 - Arg 429 (Accession # Q9UK05-1).
