The Insulin-like Growth Factor 1 Receptor (IGF1) is also known as CD221, JTK13.
and is a transmembrane receptor that is activated by IGF-1 and by the related growth factor IGF-2.
It belongs to the large class of tyrosine kinase receptors.
This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin.
IGF1R is make up of two alpha subunits and two beta subunits ,the Both the α and β subunits are synthesized from a single mRNA precursor.
The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain.The α chains are located extracellularly while the β subunit spans the membrane and are responsible for intracellular signal transduction upon ligand stimulation.
IGF1R have a binding site for ATP, which is used to provide the phosphates for autophosphorylation.
There is a 60% homology between IGF1R and the insulin receptor.
In response to ligand binding, the α chains induce the tyrosine autophosphorylation of the β chains.
This event triggers a cascade of intracellular signaling that, while somewhat cell type specific, often promotes cell survival and cell proliferation.
特徴
This protein contains a furin convertase cleavage site, 737-RKRR-740, and will be partially processed into N (α chain) and C-terminal fragment (partial β chain) with calculated MW of 81.0 kDa and 25.6 kDa respectively.
The protein migrates as 45-50 kDa (partial β chain), 110-120 kDa (α chain).
仕様
容量：25ug
Source：Biotinylated Human IGF-I R, His,Avitag (IGR-H82E3) is expressed from human 293 cells (HEK293). It contains AA Glu 31 - Asn 932 (Accession # P08069-1).
