Fibroblast growth factor (FGF)19 is the first members of a new subfamily of FGFs and could act as hormones.
During fetal life, FGF15/19 is involved in organogenesis, affecting the development of the ear, eye, heart, and brain.
FGFs–FGFRs are involved in regulation of many biological processes such as embryonic development, cell proliferation, differentiation, and tissue repair.
The dysregulation of FGF–FGFR was observed in different types of diseases, disorders, and cancers.
Notably, aberrant expression of FGF19/FGFR4 contributes to Hepatocellular Carcinoma progression.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 47.9 kDa.
The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human FGF19, Fc Tag (FG9-H5253) is expressed from human 293 cells (HEK293). It contains AA Leu 25 - Lys 216 (Accession # O95750-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Leu 25 - Lys 216
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：O95750-1
Protein ID：NP_005108.1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
