Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers, which is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to Z-disc and costamere structures.
It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity.
Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro).
ITGA7 has been shown to interact with Merosin, ITGB1, FHL2 and FHL3.
特徴
Biotinylated Human ITGA7X2B & ITGB1 Heterodimer Protein, produced by co-expression of ITGA7X2B and ITGB1, has a calculated MW of 116.9 kDa (ITGA7X2B) and 86.7 kDa (ITGB1).
Subunit ITGA7X2B is fused with an acidic tail but no tag at the C-terminus and subunit ITGB1 contains a basic tail at the C-terminus and followed by a polyhistidine tag and an Avi tag (Avitag).
The non-reducing (NR) protein migrates as 100-115 kDa due to glycosylation.
仕様
容量：25ug
Source：Biotinylated Human ITGA7X2B&ITGB1 Heterodimer Protein, Tag Free&His,Avitag (IT1-H82W5) is expressed from human 293 cells (HEK293). It contains AA Phe 34 - Trp 1038 (ITGA7X2B) & Gln 21 - Asp 728 (ITGB1) (Accession # Q13683-7 (ITGA7X2B) & P05556-1 (ITGB1)).
