MAGP-2 (Microfibril-associated glycoprotein 2), also called MFAP5 (microfibrillar associated protein 5) is a secreted, cell-associated 25 kDa mammalian member of the MFAP family of proteins.
Both MAGP-1 and MAGP-2 bind and covalently crosslink Fibrillin-1 and -2 through the Cys-rich binding domain.
Functionally, the MAGP-2 RGD motif binds to the integrin alpha v beta 3, allowing cell attachment to microfibrils.
MAGP‑2 is thought to facilitate microfibril assembly and induce elastin fiber formation.
Through its binding to EGF repeats, MAGP‑2 mediates the metalloproteinase-dependent release of Jagged1, and the metalloproteinase-independent release of Notch extracellular domains.
In endothelial cells, MAGP-2 promotes angiogenic sprouting by inhibiting Notch signaling, by binding to integrin alpha v beta 3 (which then enhances VEGF signaling), and/or enhancing the endothelial cell response to FGF basic and EGF.
In ovarian cancer, MAGP-2 expression is associated with cancer cell survival, increased microvessel density, and poor prognosis.
特徴
This protein carries a Fc tag at the C-terminus.
This protein contains a furin convertase cleavage site, 149-RRLR-152, and will be partially processed into N and C-terminal fragment with calculated MW of 43.7 kDa and 29.1 kDa respectively.
The protein migrates as 55-66 kDa and 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human MAGP-2, Fc Tag (MA2-H5254) is expressed from human 293 cells (HEK293). It contains AA Ile 22 - Leu 173 (Accession # Q13361-1).
