83-3856-23　Human VEGF165 Protein, His Tag 1mg　VE5-H5248-1mg

特徴

• 背景
• VEGF165 is the most abundant splice variant of VEGF-A.
• VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells.
• VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability.
• VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes.
• VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix.
• VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2.
• VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling.
• Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin.
• VEGF plays a key role in tumor angiogenesis in many cancers.
• 特徴
• This protein carries a polyhistidine tag at the N-terminus.
• The protein has a calculated MW of 21.1 kDa.
• The protein migrates as 25-27 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.