Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) ,a member of the peptidase C12 family, is also known as neuron cytoplasmic protein 9.5 (PGP 9.5) and ubiquitin thioesterase L1.About 30% of total UCHL1 is associated with membranes in brain.
UCHL1 is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins.
This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin.
Also,UCHL1 can bind to free monoubiquitin and may prevent its degradation in lysosomes.
The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity.
Furthermore, the mutations of UCHL1 gene can result in parkinson disease 5.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 25.7 kDa.
The protein migrates as 27-28 kDa under reducing (R) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human UCH-L1, His Tag (UC1-H5140) is expressed from E. coli cells. It contains AA Gln 2 - Ala 223 (Accession # NP_004172).
