Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells.
Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5).
Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment.
Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 17.1 kDa.
The protein migrates as 8-10 kDa, 15-20 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus TSLP, His Tag (TSP-C52H8) is expressed from human 293 cells (HEK293). It contains AA Tyr 29 - Gln 159 (Accession # A0A7N9CAT7-1).
