Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily.
TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats.
TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.
APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL.
The adapter molecule FADD recruits caspase-8 to the activated receptor.
The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 24.8 kDa.
The protein migrates as 20-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human TRAIL R1, His Tag (TR1-H5228) is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Asn 239 (Accession # O00220-1).
