83-3855-25 Human TOP2A / TOP2 Protein, Tag Free 100ug TOA-H5117-100ug
特徴
- 背景
- DNA topoisomerase 2-alpha (TOP2A) is also known as DNA topoisomerase II, alpha isozyme and TOP2.
- It is a topoisomerase which control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands.
- Topoisomerase II makes double-strand breaks.
- Essential during mitosis and meiosis for proper segregation of daughter chromosomes.
- May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation.
- Also it is the targets of anti-cancer drugs that cause treatment-related leukemias with balanced translocations.
- 特徴
- This protein carries no "tag".
- The protein has a calculated MW of 12.8 kDa.
- The protein migrates as 20 kDa under reducing (R) condition (SDS-PAGE).
仕様
- 容量：100ug
- Source：Human TOP2A, Tag Free (TOA-H5117) is expressed from E. coli cells. It contains AA Ser 1354 - Ser 1473 (Accession # P11388-1).
- Species Reactivity：Human
- Host：E. coli
- Tag：Native
- Exp Region：Ser 1354 - Ser 1473
- Format：Liquid
- Conjugate：Unconjugated
- Swiss-Prot：P11388-1
- Protein ID：NP_001058.2
- Endotoxin：1.0 EU per μg
- Purity：90%
- Buffer：50 mM Tris, 0.5 M KCl, pH8.0
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