83-3855-22 Human Osteoprotegerin / TNFRSF11B Protein, Fc Tag 1mg TNB-H5259-1mg
特徴
- 背景
- Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) is also known as Osteoclastogenesis inhibitory factor (OCIF), Osteoprotegerin (OPG).
- TNFRSF11B is a secreted homodimer protein, which can interact with TNFSF10 and TNFSF11.
- TNFRSF11B acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
- TNFRSF11B inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro.
- Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B.
- TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
- 特徴
- This protein carries a human IgG1 Fc tag at the C-terminus.
- The protein has a calculated MW of 70.2 kDa.
- The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
- 容量：1mg
- Source：Human Osteoprotegerin, Fc Tag (TNB-H5259) is expressed from human 293 cells (HEK293). It contains AA Glu 22 - Leu 401 (Accession # NP_002537).
- Species Reactivity：Human
- Host：HEK293
- Tag：C-Fc
- Exp Region：Glu 22 - Leu 401
- Format：Powder
- Conjugate：Unconjugated
- Swiss-Prot：O00300
- Protein ID：NP_002537
- Endotoxin：1.0 EU per μg
- Purity：92%
- Buffer：50 mM Tris, 100 mM Glycine, pH7.5
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