Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) is also known as Decoy Receptor 3 (DcR3), Decoy receptor for Fas ligand and M68, which belongs to the tumor necrosis factor receptor superfamily.
TNFRSF6 is a soluble protein which contains four TNFR-Cys repeats.
Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.
TNFRSF6B acts as a decoy receptor that competes with death receptors for ligand binding.
The protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 56.2 kDa.
The protein migrates as 60-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human DcR3, Fc Tag (TNB-H5255) is expressed from human 293 cells (HEK293). It contains AA Val 30 - His 300 (Accession # O95407-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Val 30 - His 300
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：O95407-1
Protein ID：AAH17065
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
