83-3855-03 Human CLEC4C / BDCA2 Protein, Fc Tag 1mg CLC-H5254-1mg
特徴
- 背景
- CLEC4C (C-type lectin domain family 4 member C), also known as BDCA2, CLECSF11, CLECSF7, DLEC and CD303.
- Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cell.
- Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man.
- Binds to serum IgG.
- Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells.
- May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells.
- May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium.
- 特徴
- This protein carries a human IgG1 Fc tag at the N-terminus.
- The protein has a calculated MW of 46.4 kDa.
- The protein migrates as 55-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
- 容量：1mg
- Source：Human CLEC4C, Fc Tag (CLC-H5254) is expressed from human 293 cells (HEK293). It contains AA Asn 45 - Ile 213 (Accession # Q8WTT0-1).
- Species Reactivity：Human
- Host：HEK293
- Tag：N-Fc
- Exp Region：Asn 45 - Ile 213
- Format：Powder
- Conjugate：Unconjugated
- Swiss-Prot：Q8WTT0-1
- Protein ID：NP_569708.1
- Endotoxin：1.0 EU per μg
- Purity：95%
- Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
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