Transferrin receptor protein 2 (TFR2) is a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain.
The mutations in TFR2 gene have been associated with hereditary hemochromatosis type III.
Furthermore, TFR2 is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.
特徴
This protein carries a mouse IgG1 Fc tag at the N-terminus.
The protein has a calculated MW of 101.1 kDa.
The protein migrates as 116 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Mouse TFR2, Mouse Fc Tag (TF2-M5269) is expressed from human 293 cells (HEK293). It contains AA Arg 103 - Phe 798 (Accession # Q9JKX3-1).
Species Reactivity：Mouse
Host：HEK293
Tag：N-mFc(mIgG1)
Exp Region：Arg 103 - Phe 798
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q9JKX3-1
Protein ID：NP_056614.3
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
