Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family.
Siglecs are cell surface proteins that bind sialic acid.
They are found primarily on the surface of immune cells and are a subset of the I-type lectins.
Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail.
Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation.
Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.
特徴
This protein carries a mouse IgG2a Fc tag at the C-terminus.
The protein has a calculated MW of 53.4 kDa.
The protein migrates as 55-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Siglec-15, Mouse IgG2a Fc Tag (SG5-H5254) is expressed from human 293 cells (HEK293). It contains AA Phe 20 - Thr 263 (Accession # Q6ZMC9-1).
Species Reactivity：Human
Host：HEK293
Tag：C-mFc(mIgG2a)
Exp Region：Phe 20 - Thr 263
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q6ZMC9-1
Protein ID：NP_998767.1
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
