P-selectin (SELP) is also known as CD62 antigen-like family member P, granule membrane protein 140 (GMP-140), leukocyte-endothelial cell adhesion molecule 3 (LECAM3) and platelet activation dependent granule-external membrane protein (PADGEM).
SELP functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells, which line the inner surface of blood vessels, and activated platelets.
In unactivated endothelial cells, it is stored in granules called Weibel-Palade bodies.
In unactivated platelets SELP is stored in α-granules.
The primary ligand for SELP is P-selectin glycoprotein ligand-1 (PSGL-1) which is expressed on almost all leukocytes, although P-selectin also binds to heparan sulfate and fucoidan.
Furthermore, SELP has a functional role in metastasis of tumor similar to E-selectin, which can help cancer cells invade into bloodstream for metastasis and provided locally with multiple growth factors respectively.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 106.6 kDa.
The protein migrates as 130-180 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
仕様
容量：100ug
Source：Human P-Selectin, Fc Tag (SEP-H5255) is expressed from human 293 cells (HEK293). It contains AA Trp 42 - Ala 771 (Accession # AAN06828).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Trp 42 - Ala 771
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P16109
Protein ID：AAN06828
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
