E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled.
Acts on both canonical and non-canonical Wnt signaling pathway.
Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity)
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 43.5 kDa.
The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human RNF43, Fc Tag (RN3-H5256) is expressed from human 293 cells (HEK293). It contains AA Gln 44 - Tyr 197 (Accession # Q68DV7-1).
