Receptor-type tyrosine-protein phosphatase delta is an enzyme that is encoded by the PTPRD gene.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family.
PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
PTPRD has been shown to interact with PTPRS and liprin-alpha-1.
Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance.
Multiple tissue specific alternatively spliced transcript variants of this gene have been reported.
Mutations in the PTPRD gene are associated with autism, obsessive–compulsive disorder, and breast cancer.
特徴
This protein carries a polyhistidine tag at the C-terminus.
This protein contains a furin-like convertase cleavage site, 1178-RSIR-1181, and will be processed into N and C-terminal fragment with calculated MW of 128.6 kDa and 11.5 kDa respectively.
The protein migrates as 116-130 kDa and 12-14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human PTPRD, His Tag (PTD-H52H9) is expressed from human 293 cells (HEK293). It contains AA Glu 21 - Glu 1265 (Accession # P23468-1).
