83-3853-41　Biotinylated Human Prolactin / PRL Protein, Fc,Avitag 25ug　PRN-H82F7-25ug

特徴

• 背景
• Prolactin (gene name PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation, but has pleiotropic effects in both males and females.
• Prolactin is synthesized as a prohormone.
• Following cleavage of the signal peptide, the length of the mature hormone is between 194 and 199 amino acids, depending on species.
• Hormone structure is stabilized by three intramolecular disulfide bonds.
• Excessive secretion of prolactin - hyperprolactinemia - is a relative common disorder in humans.
• This condition has numerous causes, including prolactin-secreting tumors and therapy with certain drugs.
• The prolactin receptor (gene name PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family.
• Expression of the prolactin receptor is widespread.
• Each prolactin molecule is thought to bind two receptor molecules
• 特徴
• This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
• The protein has a calculated MW of 51.2 kDa.
• The protein migrates as 57-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.