Prolactin (gene name PRL) is a secreted neuroendocrine pituitary hormone that acts primarily on the mammary gland to promote lactation, but has pleiotropic effects in both males and females.
Prolactin is synthesized as a prohormone.
Following cleavage of the signal peptide, the length of the mature hormone is between 194 and 199 amino acids, depending on species.
Hormone structure is stabilized by three intramolecular disulfide bonds.
Excessive secretion of prolactin - hyperprolactinemia - is a relative common disorder in humans.
This condition has numerous causes, including prolactin-secreting tumors and therapy with certain drugs.
The prolactin receptor (gene name PRLR) is a transmembrane type I glycoprotein that belongs to the cytokine hematopoietic receptor family.
Expression of the prolactin receptor is widespread.
Each prolactin molecule is thought to bind two receptor molecules
特徴
This protein carries a mouse IgG2a Fc tag at the C-terminus.
The protein has a calculated MW of 49.8 kDa.
The protein migrates as 50-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Prolactin Protein, Mouse IgG2a Fc Tag (PRN-H5257) is expressed from human 293 cells (HEK293). It contains AA Leu 29 - Cys 227 (Accession # Q5THQ0-1).
Species Reactivity：Human
Host：HEK293
Tag：C-mFc(mIgG2a)
Exp Region：Leu 29 - Cys 227
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q5THQ0-1
Protein ID：NP_000939.1
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
