Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis.
The main source of PGF during pregnancy is the placental trophoblast.
PGF is also expressed in many other tissues, including the villous trophoblast.
PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration.
PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner.
Also promotes cell tumor growth.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 41.2 kDa.
The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：500ug
Source：Human PlGF-1 Protein, Fc Tag (PGF-H5256) is expressed from human 293 cells (HEK293). It contains AA Leu 19 - Arg 149 (Accession # P49763-2).
