83-3852-50　［取扱停止］Human Neuregulin-4 / NRG4 Protein, His Tag 1mg　NR4-H52H3-1mg

特徴

• 背景
• Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.
• Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.
• The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation.
• Furthermore, NRG4 is a low affinity ligand for the ERBB4 tyrosine kinase receptor.
• Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.
• NRG4 does not bind to the ERBB1, ERBB2 and ERBB3 receptors.
• 特徴
• This protein carries a polyhistidine tag at the C-terminus.
• The protein has a calculated MW of 8.6 kDa.
• The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.