NOTCH1 Interacts with DNER, DTX1, DTX2 and RBPJ/RBPSUH.
Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1.
The NOTCH1 intracellular domain interacts with SNW1; the interaction involves multimerized NOTCH1 NICD and is implicated in a formation of an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ.
The activated membrane-bound form interacts with AAK1 which promotes NOTCH1 stabilization.
Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination.
Involved in the maturation of both CD4+ and CD8+ cells in the thymus.
Important for follicular differentiation and possibly cell fate selection within the follicle.
During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 55.4 kDa.
The protein migrates as 58-68 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Mouse NOTCH1, His Tag (NO1-M52H8) is expressed from human 293 cells (HEK293). It contains AA Ala 19 - Gln 526 (Accession # Q01705-1).
