Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding.
Its association with UNC5 proteins may trigger signaling for axon repulsion.
It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Implicated as a tumor suppressor gene.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 119.6 kDa.
The protein migrates as 125-150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Netrin receptor DCC, His Tag (NEC-H52H3) is expressed from human 293 cells (HEK293). It contains AA Phe 32 - Asn 1097 (Accession # P43146-1).
