Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding.
Its association with UNC5 proteins may trigger signaling for axon repulsion.
It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Implicated as a tumor suppressor gene.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 144.1 kDa.
The protein migrates as 140-160 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Netrin receptor DCC, Fc Tag (NEC-H5254) is expressed from human 293 cells (HEK293). It contains AA Phe 32 - Asn 1097 (Accession # P43146-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Phe 32 - Asn 1097
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P43146-1
Protein ID：NP_005206.2
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
