Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction.
MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites.
Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.
Probably plays a role in maintaining homeostasis on mucosal surfaces.
特徴
This protein carries a llama IgG2b Fc tag at the C-terminus.
The protein has a calculated MW of 42.4 kDa.
The protein migrates as 50-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human Mucin-1 Protein, Llama IgG2b Fc Tag (MU1-H5255) is expressed from human 293 cells (HEK293). It contains AA Ser 33 - Gly 167 (Accession # AAI20976).
Species Reactivity：Human
Host：HEK293
Tag：C-LlamaFc(LlamaIgG2b)
Exp Region：Ser 33 - Gly 167
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：AAI20976
Protein ID：NP_001018016.1
Endotoxin：0.01 EU per μg
Purity：90%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
