Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction.
MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites.
Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization.
Probably plays a role in maintaining homeostasis on mucosal surfaces.
特徴
This protein carries a polyhistidine tag at the C-terminus.The mature form of Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved partial α and partial β chain.
Each partial α and partial β chain has a calculated MW of 7.2 kDa (partial α chain) and 8.3 kDa (partial β chain).
The protein migrates as 14 kDa (uncleaved), 12 kDa (partial α chain) and 11 kDa (partial β chain) under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Cynomolgus Mucin-1, His Tag (MU1-C52H5) is expressed from human 293 cells (HEK293). It contains AA Leu 254 - Gly 373 (Accession # XP_005541632.1).
