Nectin-4 (gene name PVRL4, poliovirus receptor-like 4) is a 66 kDa type I transmembrane glycoprotein belonging to the Nectin family of Ig superfamily proteins.
Nectins are cell adhesion molecules that play a key role in various biological processes such as polarity, proliferation, differentiation and migration, for epithelial, endothelial, immune and neuronal cells, during development and adult life.
Nectin-4 is a tumor-associated antigen in 50%, 49% and 86%o of breast, ovarian and lung carcinomas, respectively, mostly on tumors of bad prognosis.
Its expression is not detected in the corresponding normal tissues.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 61.1 kDa.
The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Rat Nectin-4, Fc Tag (NE4-R5255) is expressed from human 293 cells (HEK293). It contains AA Tyr 28 - Val 348 (Accession # D3ZET1-1).
Species Reactivity：Rat
Host：HEK293
Tag：C-Fc
Exp Region：Tyr 28 - Val 348
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：D3ZET1-1
Protein ID：NP_001102546.1
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
