CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3).
CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages.
CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells.
In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 22.3 kDa.
The protein migrates as 30-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human CD58, His Tag (LF3-H5225) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Arg 215 (Accession # AAH05930).
