83-3851-08　Human JAK1 Protein, His Tag 1mg　JA1-H5547-1mg

特徴

• 背景
• JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines.
• It interacts with the common gamma chain (γc) of type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g.
• IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g.
• IL-4R and IL-13R), the gp130 receptor family (e.g.
• IL-6R, IL-11R, LIF-R, OSM-R, cardiotrophin-1 receptor (CT-1R), ciliary neurotrophic factor receptor (CNTF-R), neurotrophin-1 receptor (NNT-1R) and Leptin-R).
• Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families.
• Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body
• 特徴
• This protein carries a polyhistidine tag at the N-terminus.
• The protein has a calculated MW of 35.7 kDa.
• The protein migrates as 30-33 kDa under reducing (R) condition (SDS-PAGE).