Integrin alpha E beta 7 consist of two major subunits: Integrin alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) and Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.
Integrin alpha E beta 7 (CD103) is expressed mainly by cells of the T lymphocyte lineage within mucosal tissues.
This is a strikingly narrow pattern of expression compared with that of other integrins.
Lymphocytes expressing alpha E beta 7 are abundant in the gut and comprise a major part of the total T cell complement of the body.The effectiveness of lung transplantation is marred by the relatively high incidence of rejection.
The lung normally contains a large population of lymphocytes in contact with the airway epithelium, a proportion of which expresses the mucosal integrin, alpha(E)(CD103)beta(7).
This integrin is not a homing receptor, but is thought to retain lymphocytes at the epithelial surface.
特徴
Human ITGAE&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAE and ITGB7, has a calculated MW of 128.6 kDa (ITGAE) and 81.8 kDa (ITGB7).
The protein migrates as 100-115 kDa and 135-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human ITGAE&ITGB7 Heterodimer Protein, His Tag&Tag Free (IT7-H52W7) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Ser 1124 (ITGAE) & Glu 20 - His 723 (ITGB7) (Accession # P38570-1 (ITGAE) & P26010-1 (ITGB7)).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His | Native
Exp Region：Phe 19 - Ser 1124 (ITGAE) & Glu 20 - His 723 (ITGB7)
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P38570-1 (ITGAE) & P26010-1 (ITGB7)
Protein ID：NP_002199.3 (ITGAE) & NP_000880.1 (ITGB7)
